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Arimidex is indicated for the first-line treatment of postmenopausal women with hormone receptor-positive or hormone receptor unknown locally advanced or metastatic breast cancer
Arimidex is used to treat breast cancer in postmenopausal women. It is often given to women whose cancer has progressed even after taking tamoxifen
The required dose of Arimidex is one 1 mg tablet taken once a day. For patients with advanced breast cancer, Arimidex should be continued until tumor progression. Arimidex can be taken with or without food.
For adjuvant treatment of early breast cancer in postmenopausal women, the optimal duration of therapy is unknown. In the ATAC trial.
No changes in dose are recommended for patients with mild-to-moderate hepatic impairment
Anastrozole may cause fetal harm when administered to a pregnant woman and offers no clinical benefit to premenopausal women with breast cancer. Anastrozole is contraindicated in women who are or may become pregnant. There are no adequate and wellcontrolled studies in pregnant women using ARIMIDEX
Consider risk and benefits of Anastrozole therapy in patients with pre-existing ischemic heart disease
Results from the ATAC trial bone substudy at 12 and 24 months demonstrated that patients receiving Anastrozole had a mean decrease in both lumbar spine and total hip bone mineral density (BMD) compared to baseline.
During the ATAC trial, more patients receiving Anastrozole were reported to have elevated serum cholesterol compared to patients receiving tamoxifen
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